研究業績

Matsuzaki K, Sugimoto N, Hossain S, Islam R, Sumiyoshi E, Hashimoto M, Kishi H, Shido O, Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats, Food Funct, 15: 5579-5595, 2024

Kishi H, The Signal Transduction of Abnormal Vascular Smooth Muscle Contraction, Shimane J Med Sci, 41: 1-7, 2024

Zhang Y, Zheng H, Xu M, Maeda N, Tsunedomi R, Kishi H, Nagano H, Kobayashi S, Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells, Int J Mol Sci, 15980, 24, 2023

Zhang Y, Kishi H, Kobayashi S, Direct active Fyn-paxillin interaction regulates vascular smooth muscle cell migration, J Smooth Muscle Res, 59: 58-66, 2023

Hosoba K, Morita T, Zhang Y, Kishi H, Yamamoto T, Miyamoto T, High-efficient CRISPR/Cas9-mediated gene targeting to establish cell models of ciliopathies, Methods Cell Biol, 175: 85-95, 2023

Li N, Zhang Y, Morita T, Kishi H, Kobayashi S, Inhibitory mechanism of tangeretin, a citrus flavone on the sphingosylphosphorylcholine (SPC)-induced vascular smooth muscle contraction, J Pharmacol Sci, 149(4): 189-197, 2022

Lu Q, Kishi H, Zhang Y, Morita T, Kobayashi S, Hesperetin inhibits sphingosylphosphorylcholine-induced vascular smooth muscle contraction by regulating the Fyn/Rho-kinase pathway, J Cardiovasc Pharmacol, 79: 456-466, 2022,

Zhang Y, Kishi H, Morita T, Kobayashi S, Paxillin controls actin stress fiber formation and migration of vascular smooth muscle cells by directly binding to the active Fyn, FASEB J, 35(12): e22012, 2021

Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn, Kurahara LH, Hiraishi K, Yamamura A, Zhang Y, Abe K, Yahiro E, Aoki M, Koga K, Yokomise H, Go T, Ishikawa K, Bo Z, Kishi H, Kobayashi S, Aoki-Shoi N, Toru S, Inoue R, Hirano K, JJ Mol Cell Cardiol, 148: 50-62, 2020

Kawamura A, Inagaki J, Umemoto S, Kajiya K, Kishi H, Mitarai M, Oda H, Kobayashi S, Dietary Adherence, Self-Efficacy, and Health Behavior Change of WASHOKU-modified DASH Diet: A Sub-analysis of the DASH-JUMP Study, Curr Hypertens Rev, 15: 1-10, 2019

Kawamura A, Kajiya K, Kishi H, Inagaki J, Mitarai M, Oda H, Umemoto S Kobayashi S, The nutritional characteristics of the hypotensive WASHOKU-modified DASH diet: a sub-analysis of the DASH-JUMP study, Curr Hypertens Rev, 14(1): 56-65, 2018

Zhang Y, Kishi H, Kobayashi S, Add-on therapy with traditional Chinese medicine: An efficacious approach for lipid metabolism disorders, Pharmacol Res, 134: 200-211, 2018

Zhang Y, Zhang M, Lyu B, Kishi H, Kobayashi S, Omega-3 and omega-6 DPA equally inhibit the sphingosylphosphorylcholine-induced Ca2+-sensitization of vascular smooth muscle contraction via inhibiting Rho-kinase activation and translocation, Sci Rep, 7: 36368, 2017

Kawamura A, Kajiya K, Kishi H, Inagaki J, Mitarai M, Oda H, Umemoto S, Kobayashi S, Effects of the DASH-JUMP dietary intervention in Japanese participants with high-normal blood pressure and stage 1 hypertension: an open-label single-arm trial,　Hypertens Res, 39(11): 777–785, 2016

Kagawa Y, Yasumoto Y, Sharifi K, Ebrahimi M, Islam A, Miyazaki H, Yamamoto Y, Sawada T, Kishi H, Kobayashi S, Maekawa M, Yoshikawa T, Takaki E, Nakai A, Kogo H, Fujimoto T, Owada Y, Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-1, Glia, 63(5) 780–794, 2015

An BC, Sakai T, Komaba S, Kishi H, Kobayashi S, Kim JY, Ikebe R, Ikebe M, Phosphorylation of the Kinase Domain Regulates Autophosphorylation of Myosin IIIA and Its Translocation in Microvilli, Biochemistry, 53(49): 7835–7845, 2014

Suzuki MM, Matsumoto M, Omi H, Kobayashi T, Nakamura A, Kishi H, Kobayashi S, Takagi T, Interaction of peptide-bound beads with lipopolysaccharide and lipoproteins, J Microbiol Methods, 100(4): 137–141, 2014

Xu D, Kishi H, Kawamichi H, Kajiya K, Takada Y, Kobayashi S, Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts, Cell Signal, 24(1): 282-289, 2012

Mori D, Hori M, Murata T, Ohama T, Kishi H, Kobayashi S, Ozaki H, Synchronous phosphorylation of CPI-17 and MYPT1 is essential for inducing Ca2+ sensitization in intestinal smooth muscle, Neurogastroenterol Motil, 23(12): 1111-1122, 2011

Hashimoto R, Umemoto S, Guo F, Umeji K, Itoh S, Kishi H, Kobayashi S, Matsuzaki M, Nifedipine Activates PPARγ and Exerts an Antioxidative Action Through Cu/ZnSOD Independent of Blood-pressure Lowering in SHRSP, J Atheroscler Thromb, 17(8): 785-795, 2010

Kurokawa T, Yumiya Y, Fujisawa H, Shirao S, Kashiwagi S, Sato M, Kishi H, Miwa S, Mogami K, Kato S, Akimura T, Soma M, Ogasawara K, Ogawa A, Kobayashi S, Suzuki M, Elevated concentrations of sphingosylphosphorylcholine in cerebrospinal fluid after subarachnoid hemorrhage: A possible role as a spasmogen, J Clin Neurosci, 16(8): 1064–1068, 2009

Maeda Y, Mitsumizo S, Guo F, Kishi H, Matsuo S, Kobayashi S, Nakashima M, Sivelestat relaxes porcine coronary artery via inhibition of Ca2+ sensitization induced by a receptor agonist, J Cardiovasc Pharmacol, 51(5): 476-482, 2008

Nakamura A, Xie C, Zhang Y, Gao Y, Wang HH, Ye LH, Kishi H, Yoshiyama S, Hayakawa K, Ishikawa R, Kohama K, Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi, Biochem Biophys Res Commun, 369(1): 135-143, 2008

Xu D, Kishi H, Kawamichi H, Kajiya K, Takada Y, Kobayashi S, Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts, FEBS lett, 581(27): 5227-5233, 2007

Ohama T, Hori M, Momotani E, Iwakura Y, Guo F, Kishi H, Kobayashi S, Ozaki H, Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-alpha and causes motility disorders, Am J Physiol Gastrointest Liver Physiol, 292(5): G1429-38, 2007

Morikage N, Kishi H, Sato M, Guo F, Shirao S, Yano T, Soma M, Hamano K, Esato K, Kobayashi S, Cholesterol primes vascular smooth muscle to induce Ca2+ sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft, Circ Res, 99(3): 299-306, 2006

Mogami K, Kishi H, Kobayashi S, Sphingomyelinase causes endothelium-dependent vasorelaxation through endothelial nitric oxide production without cytosolic Ca2+ elevation, FEBS Lett, 579(2): 393-397, 2005

Yoneda K, Iwamura R, Kishi H, Mizukami Y, Mogami K, Kobayashi S, Identification of the active metabolite of ticlopidine from rat in vitro metabolites, Br J Pharmacol, 142(3): 551-557, 2004

Takeda K, Kishi H, Ma XF, Yu ZX, Adelstein RS, Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis, Circ Res, 93(4):330-337, 2003

Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kazuhiro K, Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction, IUBMB Life, 51(6): 337-344, 2001

Kishi H, Bao J, Kohama K, Inhibitory effects of ML-9, wortmannin and Y-27632 on the chemotaxis of vascular smooth muscle cells in response to platelet-derived growth factor-BB, J Biochem, 128(5): 719-722, 2000

Kishi H, Mikawa T, Seto M, Sasaki Y, Toyoda TK, Yamaguchi T, Imamura M, Ito M, Karaki H, Bao J, Nakamura A, Ishikawa R, Kohama K, Stable transfectants of smooth muscle cell line lacking the expression of myosin light chain kinase and their characterization with respect to actomyosin system, J Biol Chem, 275(2): 1414-1420, 2000

Ye LH, Kishi H, Nakamura A, Okagaki T, Tanaka T, Oiwa K, Kohama K, Myosin light-chain kinase of smooth muscle stimulates myosin ATPase activity without phosphorylating myosin light chain, Proc Natl Acad Sci U S A, 96(12): 6666-6671, 1999

Kishi H, Ye LH, AkioNakamura A, Okagaki T, Iwata A, Tanaka T, Kohama K, Structure and function of smooth muscle myosin light chain kinase, Adv Exp Med Biol, 453: 229-234, 1998

Yuan L, Kishi H, Nakamura A, Takagi T, Kohama K, N-terminal myosin binding fragment of talin, Biochem Biophys Res Commun, 249(3): 656-659, 1998

Ye LH, Hayakawa K, Kishi H, Imamura M, Nakamura A, Okagaki T, Takagi T, Iwata A, Tanaka T, Kohama K, The structure and function of the actin-binding domain of myosin light chain kinase of smooth muscle, J Biol Chem, 272(51): 32182-32189, 1997